Abstract

Objective

The study aimed to characterize tumefactive demyelinating lesions by magnetic resonance imaging multicomponent T2 relaxation.

Methods

Quantitative T2 mapping of the intra/extra-cellular water was compared with conventional T2-weighted Fluid-Attenuated Inversion Recovery (FLAIR) and contrast-enhancement T1-weighted imaging.

Results

Tumefactive demyelinating lesions showed typical open-ring-like contrast enhancement, with no T2 hypointense rim on both FLAIR and T2-weighted but a clear heterogeneity in the intra/extra-cellular water maps. The intra/extra-cellular water T2 mapping showed a rim of shorter T2 in the same area of ring enhancement and a longer T2 in the central portion of the lesion.

Conclusions

Intra/extra-cellular water T2 mapping has a unique potential to evidence heterogeneity features and a rim of shorter T2 in tumefactive demyelinating lesion and deserves to be further investigated.

Cite this article as

Rozzanigo U, Bontempi P, Marangoni S, Giometto B, Farace P. T2 relaxometry in tumefactive demyelinating lesions: A case study. Current Research in MRI. 2022;1(3):82-84